Pathophysiology and Effect of Therapy
Pathophysiology and Effect of Therapy
The pathophysiology of chronic low back pain is poorly understood, but is increasingly recognized as complex and multifactorial. Progress in elucidating mechanisms has been impeded by difficulties in defining suitable animal models that are clearly relevant to the human disorder and in conducting informative physiological studies of chronic pain in humans.
Some of the above-mentioned structural abnormalities of the spine are well established as causes of low back pain. Other abnormalities do not correlate well with clinical symptoms.6 Findings such as disk herniation and facet-joint degeneration, when associated with central spinal stenosis or nerve-root impingement, have been correlated with low back pain, most often in association with sciatica or neurologic deficits. However, there is a high prevalence of such spinal abnormalities in asymptomatic persons, and such findings are poor predictors of back pain in longitudinal studies. Muscular and soft-tissue abnormalities have also been described, but their role in low back pain remains uncertain.
More recent investigations focus on alterations in the central nervous system, detected with various imaging methods, that are associated with chronic low back pain. Studies using functional MRI have shown alterations in cerebral activation, and anatomical studies have shown changes in regional volume and density in the brain. It has been suggested that these alterations may reflect or contribute to changes in central nervous system processing of sensory stimuli. However, the specific findings of these studies have not been entirely consistent with one another, and it is not clear whether the observed alterations are a cause or a consequence of chronic low back pain.
In addition, psychological and behavioral factors, including fear of movement, appear to play an important role in patients with chronic low back pain. Such patients have been shown to have altered brain-activation patterns at subcortical and cortical sites associated with emotion and postural control.25-28 Studies comparing psychosocial variables with anatomical findings have shown the former to have greater predictive value than the latter.